Preventing contamination within classified areas of an operational cleanroom is a constant battle. Cleaning and disinfection programs help mitigate contamination by removing the microorganisms and particulates introduced into the classified areas during routine operations. In general, people are considered the number one source of contamination within a cleanroom, followed by materials and equipment that are transferred in and out of the classified areas. Following proper gowning and aseptic technique procedures help to mitigate contamination introduced by people. A properly developed and implemented cleaning and disinfection program is an integral component in ensuring a cleanroom is in a constant state of control. Several components must be considered when developing and implementing a cleaning and disinfection program. To determine which cleaning and disinfectant agents will be used, firms must identify the natural flora within the facility. Performing baseline monitoring in the facility—otherwise known as in-situ monitoring—before cleaning any of the target areas ensures microorganisms can be recovered. Understanding what organisms are naturally present plays a significant role in choosing the appropriate disinfectants for a facility. The resistance of microorganisms to disinfectant agents can vary significantly. For example, vegetative bacteria are generally some of the easiest microorganisms to eradicate while mold and bacterial spores are some of the most difficult. Click Here For Complete Article Text
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