Title: From Interest in Intensification to a Factory of the Future by William Whitford and Dan Nelson

Much has been published on improvements and advances in many individual technologies for biomanufacturing. If you take a comprehensive look at the field, however, you find overlap, muddling, and even contradiction about which particular processes or aspects of technological development should be designated properly as process intensification. Although the industry is addressing such distinct goals as improved manufacturing yield, product quality, and cost-effectiveness, the names of initiatives commonly applied to accomplish those goals overlap at best. Such ambiguity and lack of precision can lead to inefficiencies and errors across the industry or even within individual companies. The Cambridge University Press dictionary defines intensification as “the fact of becoming greater, more serious, or more extreme, or of making something do this.” For modern industries in general, process intensification has been defined as “any chemical engineering development that leads to a substantially smaller, cleaner, safer, and more energy efficient technology” (2). But based on that definition, most improvements of any sort in a biomanufacturing process might be termed “intensification,” and some authors have been using the word in such a way.

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