Highly potent compounds can be defined as an active pharmaceutical ingredient (API) or intermediate with an occupational exposure limit (OEL) at or below 10 µg/m3 of air as an eight hour time-weighted average.1 These compounds may have the ability to bind to specific receptors or inhibit specific enzymes and/or have the potential to cause cancer, mutations or other detrimental biological effects. Potency can be a function of structural class but it cannot be predicted for new molecules or new biological products without sufficient testing, therefore novel compounds of unknown potency and toxicity must be treated as highly potent to ensure safe handling in development. Click Here For Complete Abstract Text
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